GNOM
Global X Genomics & Biotechnology ETF
The Global X Genomics & Biotechnology ETF seeks to invest in companies that potentially stand to benefit from further advances in the field of genomic science.
Global
EQUITY
Rules-Based
MANAGEMENT STYLE
55.6 M
ASSETS UNDER MGMT
50 bp
EXPENSES
Fund Basics
| Fund sponsor | Global X |
| Category | Global |
| Asset class | Equity |
| Website | link... |
| Inception date | Apr 05, 2019 |
| Assets (mns) | $56 |
| Expense ratio | 50 bp |
| Currency | USD |
Sector Breakdown
Fund Structure
| Regulation | Open-Ended Fund |
| Distributions | Quarterly |
| Taxation | 1099 |
| Stock selection | |
| Weighting | |
| Holdings Transparency | Full |
| Derivatives-based | No |
| Options available | Yes |
| Currency hedged | No |
| Fund of funds | No |
Top 10 Holdings
Complete list +
| ALNYLAM PHARMACEUTICALS INC | 5.9 % |
| CRISPR THERAPEUTICS AG | 5.4 % |
| AVIDITY BIOSCIENCES INC | 4.9 % |
| GUARDANT HEALTH, INC. | 4.8 % |
| ARROWHEAD PHARMACEUTICALS, INC. | 4.3 % |
| BIO-TECHNE CORPORATION | 4.0 % |
| ILLUMINA INC | 4.0 % |
| NATERA INC | 4.0 % |
| QIAGEN N.V. | 3.6 % |
| PRAXIS PRECISION MEDICINES, INC. | 3.3 % |
Constituent Breakdown
| Number of holdings | 47 |
| Herfindahl-Hirschman Index | 343 |
| Wgt avg mkt cap (mns) | $33,166 |
| Large cap (>$10bn) | 39.4% |
| Mid cap ($2-10bn) | 36.7% |
| Small cap (<$2bn) | 19.5% |
| Developed mkts. | 97.2% |
| Emerging mkts. | 2.6% |
Country Exposure
 |
UNITED STATES | 79.7 % |
 |
NETHERLANDS | 6.6 % |
 |
SWITZERLAND | 5.4 % |
 |
GERMANY | 3.3 % |
 |
CHINA | 2.3 % |
 |
BRITAIN | 1.9 % |
 |
SINGAPORE | 0.9 % |
Historical Performance
Standardized Performance (as of 10/31/2025)
| YTD | 1 YR | 2 YR | 3 YR | 5 YR | 10 YR | 20 YR | Incep. | |
|---|---|---|---|---|---|---|---|---|
| Price Returns | 367.9% | 337.7% | 126.6% | 51.2% | 20.3% | -- | -- | 18.0% |
| Dividend Yield | 0.4% | 0.4% | 0.1% | 0.0% | 0.1% | -- | -- | 0.0% |
| Total Returns | 368.4% | 338.1% | 126.7% | 51.2% | 20.3% | -- | -- | 18.0% | Ann. Volatility | 341.3% | 312.3% | 221.4% | 181.6% | 142.9% | -- | -- | 125.8% |
Market Correlations
| versus... | Beta | R-squared |
| S&P 500 | 2.67 | 3% |
| MSCI EAFE | -1.61 | 2% |
| MSCI Emg Mkts | -0.67 | 0% |
Liquidity Measures
| Avg. volume (000) | 13 |
| ADV traded (mns) | $1 |
| Turnover | 1.1% |
| Avg. Bid/Ask (% of price) | 0.58% |
Technical Indicators
| Recent close | $45.44 |
| 30d moving avg. | $41.52 |
| Annualized volatility | 189.2% |
| Relative strength (RSI) | 74 |
| Short interest | 0.3% |
Distributions
Assets Under Management (mns)
Money Flows (mns)
Short Interest (as % of shares outstanding)
Long Money Flows (mns)
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Comparable ETFs Based on Overlap
| Ticker | Fund Name | Overlap vs. |
Expenses vs. |
ALTAR Score™ vs. |
|---|---|---|---|---|
| WDNA | WisdomTree BioRevolution Fund | 32.4% | -5 bp | -2.2% |
| ARKG | ARK Genomic Revolution ETF | 31.8% | +25 bp | +0.0% |
| HELX | Franklin Genomic Advancements ETF | 28.7% | 0 bp | -0.4% |
| FBT | First Trust NYSE Arca Biotechnology Index Fund | 27.2% | +6 bp | +3.1% |
| HTEC | ROBO Global Healthcare Technology and Innovation ETF | 24.6% | +18 bp | +2.3% |
| XBI | SPDR S&P BIOTECH ETF | 23.3% | -15 bp | -2.2% |
| BBH | VanEck Biotech ETF | 22.8% | -15 bp | +5.5% |
| IBB | iShares Biotechnology ETF | 21.6% | -5 bp | 0.0% |
| IBBQ | Invesco Nasdaq Biotechnology ETF | 19.0% | -31 bp | +0.3% |
| PBE | Invesco Biotechnology & Genome ETF | 17.7% | +8 bp | +1.7% |
Risk and Returns: GNOM vs. Comps (1 YR)
Notes: Top 10 overlapping ETFs. Funds with insufficient history not shown. Some funds may overlap. Hover over data point for ticker symbol.
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Results & Estimates
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | ||
|---|---|---|---|---|---|---|---|---|
| Sales per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Earnings per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Dividends per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Book value per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- |
Return on Equity
Net Margins
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Valuation Metrics
| Fwd Est | 2024 | 2025 | 2026 | |
| Price-to-sales | --x | --x | --x | --x |
| Price-to-earnings | --x | --x | --x | --x |
| Price-to-cash flow | --x | --x | --x | --x |
| Price-to-growth | --x | --x | --x | --x |
| Price-to-book value | --x | --x | --x | --x |
| Yield | --% | --% | --x | --% |
Based on closing prices from 11/2/2025
Peer Group Comparison Sample data. Subscribe for access.
Price-to-Earnings
Price-to-Sales
Price-to-Book Value
Price-to-Cash Flow
Price-to-Growth
Dividend Yield
Historical Valuation Trends Sample data. Subscribe for access.
SHOWING:
Price-to-Earnings
Price-to-Earnings
Notes: Based on adjusted historical results for current fund constituents. May differ from results achieved by past fund constituents. Max P/E of 100x.
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ETF Research Center Rating
AVOID
Not worthwhile for most investors. A rating of AVOID is assigned to ETFs with ALTAR Scores in the lowest quintile (the bottom 20%) of their category. Often, funds in this category consist of stocks with little if any history or expectation of profitability, and as a result our fundamentally-driven analysis may be less relevant.
ALTAR Score™
GNOM
-2.7%
Cat. Avg
4.2%
ALTAR Score™ Calculation
Category Overview
There are 370 funds in the Global Equity category, with an average ALTAR Score™
of 4.2% and a standard deviation of
3.1%. GNOM's ALTAR Score™ is approximately
2.2 standard deviations
below
the category average. This places GNOM in the 1st percentile among funds in the category.
Sell Side Consensus Rating
Sell-side recommendations on the ETF's individual constituents
GNOMSELL
U/W
HOLD
O/W
BUY
Expense Analysis
| Peer Group | Rules-Based Global Equity ETFs |
| # of ETFs | 177 |
| Avg. Expense Ratio | 55.1 bp |
| Std. Deviation | 18.1 bp |
| GNOM (50 bp) Percentile rank | 39 |
Peer Group Expense Ratio Distribution
Total Cost of Ownership (TCO) Comparison
| Expense (bp) (A) |
Avg. Bid/Ask (bp) (B) |
TCO (bp) (A)+(B) |
|
|---|---|---|---|
| GNOM | 50.0 | 58.3 | 108.3 |
| Peer Avg. | 55.1 | 39.5 | 94.6 |
For a detailed cost analysis of this and any other ETF use the TCO Comparison Tool .