HELX
Franklin Genomic Advancements ETF
HELX is an actively managed portfolio of global equity securities of companies relevant to genomic discovery.
Global
EQUITY
Active
MANAGEMENT STYLE
10.5 M
ASSETS UNDER MGMT
50 bp
EXPENSES
Fund Basics
| Fund sponsor | Franklin Templeton |
| Category | Global |
| Asset class | Equity |
| Website | link... |
| Inception date | Feb 25, 2020 |
| Assets (mns) | $10 |
| Expense ratio | 50 bp |
| Currency | USD |
Sector Breakdown
Fund Structure
| Regulation | Open-Ended Fund |
| Distributions | Annually |
| Taxation | 1099 |
| Stock selection | Proprietary |
| Weighting | Proprietary |
| Holdings Transparency | Full |
| Derivatives-based | No |
| Options available | Yes |
| Currency hedged | No |
| Fund of funds | No |
Top 10 Holdings
| NATERA INC | 5.2 % |
| KRYSTAL BIOTECH, INC. | 4.8 % |
| VERTEX PHARMACEUTICALS INC | 4.8 % |
| REGENERON PHARMACEUTICALS | 4.0 % |
| MEDPACE HOLDINGS, INC. | 3.6 % |
| ELI LILLY & CO | 3.5 % |
| SAMSUNG BIOLOGICS CO., LTD. | 3.5 % |
| THERMO FISHER SCIENTIFIC INC | 3.4 % |
| ASTRAZENECA PLC-SPONS ADR | 3.0 % |
| BIONTECH SE SPONSORED ADR | 2.8 % |
Constituent Breakdown
| Number of holdings | 75 |
| Herfindahl-Hirschman Index | 248 |
| Wgt avg mkt cap (mns) | $63,395 |
| Large cap (>$10bn) | 55.6% |
| Mid cap ($2-10bn) | 34.2% |
| Small cap (<$2bn) | 6.2% |
| Developed mkts. | 94.6% |
| Emerging mkts. | 3.5% |
Country Exposure
 |
UNITED STATES | 81.3 % |
 |
GERMANY | 5.2 % |
 |
SOUTH KOREA | 3.5 % |
 |
BRITAIN | 3.0 % |
 |
NETHERLANDS | 2.4 % |
 |
SWITZERLAND | 1.7 % |
Historical Performance
Standardized Performance (as of 04/30/2025)
| YTD | 1 YR | 2 YR | 3 YR | 5 YR | 10 YR | 20 YR | Incep. | |
|---|---|---|---|---|---|---|---|---|
| Price Returns | -5.6% | -9.4% | -4.5% | -5.8% | 0.6% | -- | -- | 2.5% |
| Dividend Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.1% | -- | -- | 0.1% |
| Total Returns | -5.6% | -9.4% | -4.5% | -5.8% | 0.7% | -- | -- | 2.6% | Ann. Volatility | 30.7% | 23.5% | 20.5% | 23.4% | 26.6% | -- | -- | 28.6% |
Market Correlations
| versus... | Beta | R-squared |
| S&P 500 | 1.04 | 70% |
| MSCI EAFE | 0.88 | 53% |
| MSCI Emg Mkts | 0.64 | 28% |
Liquidity Measures
| Avg. volume (000) | 1 |
| ADV traded (mns) | $0 |
| Turnover | 0.3% |
| Avg. Bid/Ask (% of price) | 0.26% |
Technical Indicators
| Recent close | $26.19 |
| 30d moving avg. | $26.23 |
| Annualized volatility | 20.5% |
| Relative strength (RSI) | 43 |
| Short interest | 0.1% |
Distributions
Assets Under Management (mns)
Money Flows (mns)
Short Interest (as % of shares outstanding)
Long Money Flows (mns)
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Comparable ETFs Based on Overlap
| Ticker | Fund Name | Overlap vs. |
Expenses vs. |
ALTAR Score™ vs. |
|---|---|---|---|---|
| WDNA | WisdomTree BioRevolution Fund | 37.0% | -5 bp | -1.7% |
| BBH | VanEck Biotech ETF | 31.2% | -15 bp | +6.1% |
| HTEC | ROBO Global Healthcare Technology and Innovation ETF | 30.7% | +18 bp | +2.6% |
| IBB | iShares Biotechnology ETF | 30.2% | -5 bp | +0.9% |
| FBT | First Trust NYSE Arca Biotechnology Index Fund | 29.4% | +6 bp | +5.7% |
| SYNB | Putnam BioRevolution ETF | 28.4% | +20 bp | +2.9% |
| XBI | SPDR S&P BIOTECH ETF | 28.0% | -15 bp | -3.3% |
| IBBQ | Invesco Nasdaq Biotechnology ETF | 26.7% | -31 bp | +0.8% |
| GNOM | Global X Genomics & Biotechnology ETF | 24.8% | 0 bp | -4.2% |
| BMED | Future Health ETF | 23.8% | +35 bp | +0.5% |
Risk and Returns: vs. Comps (1 YR)
Notes: Top 10 overlapping ETFs. Funds with insufficient history not shown. Some funds may overlap. Hover over data point for ticker symbol.
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Results & Estimates
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | ||
|---|---|---|---|---|---|---|---|---|
| Sales per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Earnings per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Dividends per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Book value per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- |
Return on Equity
Net Margins
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Valuation Metrics
| Fwd Est | 2024 | 2025 | 2026 | |
| Price-to-sales | --x | --x | --x | --x |
| Price-to-earnings | --x | --x | --x | --x |
| Price-to-cash flow | --x | --x | --x | --x |
| Price-to-growth | --x | --x | --x | --x |
| Price-to-book value | --x | --x | --x | --x |
| Yield | --% | --% | --x | --% |
Based on closing prices from 5/18/2025
Peer Group Comparison Sample data. Subscribe for access.
Price-to-Earnings
Price-to-Sales
Price-to-Book Value
Price-to-Cash Flow
Price-to-Growth
Dividend Yield
Historical Valuation Trends Sample data. Subscribe for access.
SHOWING:
Price-to-Earnings
Price-to-Earnings
Notes: Based on adjusted historical results for current fund constituents. May differ from results achieved by past fund constituents. Max P/E of 100x.
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ETF Research Center Rating
AVOID
Not worthwhile for most investors. A rating of AVOID is assigned to ETFs with ALTAR Scores in the lowest quintile (the bottom 20%) of their category. Often, funds in this category consist of stocks with little if any history or expectation of profitability, and as a result our fundamentally-driven analysis may be less relevant.
ALTAR Score™
-0.2%
Cat. Avg
4.6%
ALTAR Score™ Calculation
Category Overview
There are 365 funds in the Global Equity category, with an average ALTAR Score™
of 4.6% and a standard deviation of
3.5%. 's ALTAR Score™ is approximately
1.4 standard deviations
below
the category average. This places in the 9th percentile among funds in the category.
Sell Side Consensus Rating
Sell-side recommendations on the ETF's individual constituents
HELXSELL
U/W
HOLD
O/W
BUY
Expense Analysis
| Peer Group | Active Global Equity ETFs |
| # of ETFs | 118 |
| Avg. Expense Ratio | 73.5 bp |
| Std. Deviation | 29.8 bp |
| (50 bp) Percentile rank | 24 |
Peer Group Expense Ratio Distribution
Total Cost of Ownership (TCO) Comparison
| Expense (bp) (A) |
Avg. Bid/Ask (bp) (B) |
TCO (bp) (A)+(B) |
|
|---|---|---|---|
| 50.0 | 0.0 | 50 | |
| Peer Avg. | 63.4 | 26.3 | 89.7 |
For a detailed cost analysis of this and any other ETF use the TCO Comparison Tool .