IBB
iShares Biotechnology ETF
The iShares Nasdaq Biotechnology Index Fund seeks investment results that correspond generally to the price and yield performance, before fees and expenses, of companies primarily engaged in the biotechnology industry, as represented by the NASDAQ Biotechnology Index.
US
EQUITY
Passive
MANAGEMENT STYLE
5.6 B
ASSETS UNDER MGMT
45 bp
EXPENSES
Fund Basics
| Fund sponsor | Barclays Global Investors |
| Category | US |
| Asset class | Equity |
| Website | link... |
| Inception date | Feb 05, 2001 |
| Assets (mns) | $5,589 |
| Expense ratio | 45 bp |
| Currency | USD |
Sector Breakdown
Fund Structure
| Regulation | Open-Ended Fund |
| Distributions | Quarterly |
| Taxation | 1099 |
| Stock selection | NASDAQ - Listed |
| Weighting | Market Cap |
| Holdings Transparency | Full |
| Derivatives-based | No |
| Options available | Yes |
| Currency hedged | No |
| Fund of funds | No |
Top 10 Holdings
Complete list +
| VERTEX PHARMACEUTICALS INC | 9.6 % |
| GILEAD SCIENCES INC | 8.6 % |
| AMGEN INC | 8.4 % |
| REGENERON PHARMACEUTICALS | 7.2 % |
| ALNYLAM PHARMACEUTICALS INC | 3.5 % |
| ARGENX SE ADR | 3.1 % |
| IQVIA HOLDINGS INC | 3.1 % |
| METTLER-TOLEDO INTERNATIONAL | 2.5 % |
| WATERS CORP | 2.3 % |
| NATERA INC | 2.3 % |
Constituent Breakdown
| Number of holdings | 260 |
| Herfindahl-Hirschman Index | 385 |
| Wgt avg mkt cap (mns) | $51,269 |
| Large cap (>$10bn) | 68.9% |
| Mid cap ($2-10bn) | 20.2% |
| Small cap (<$2bn) | 10.5% |
| Developed mkts. | 99.8% |
| Emerging mkts. | 0.2% |
Country Exposure
 |
UNITED STATES | 85.3 % |
 |
NETHERLANDS | 3.5 % |
 |
GERMANY | 2.0 % |
 |
DENMARK | 2.0 % |
 |
CHINA | 1.8 % |
 |
BRITAIN | 0.9 % |
 |
IRELAND | 0.6 % |
Historical Performance
Standardized Performance (as of 04/30/2025)
| YTD | 1 YR | 2 YR | 3 YR | 5 YR | 10 YR | 20 YR | Incep. | |
|---|---|---|---|---|---|---|---|---|
| Price Returns | -4.3% | -0.3% | -1.5% | 2.8% | 0.4% | 1.3% | 9.4% | 5.6% |
| Dividend Yield | 0.1% | 0.3% | 0.3% | 0.3% | 0.3% | 0.2% | 0.2% | 0.2% |
| Total Returns | -4.2% | 0.0% | -1.2% | 3.1% | 0.7% | 1.5% | 9.6% | 5.8% | Ann. Volatility | 26.9% | 21.0% | 18.9% | 21.6% | 22.7% | 24.5% | 23.6% | 26.1% |
Market Correlations
| versus... | Beta | R-squared |
| S&P 500 | 0.73 | 51% |
| MSCI EAFE | 0.67 | 45% |
| MSCI Emg Mkts | 0.46 | 21% |
Liquidity Measures
| Avg. volume (000) | 2,043 |
| Turnover | 4.6% |
| Avg. Bid/Ask (% of price) | 0.01% |
| ADV of underlying (mns) | $7,070 |
Technical Indicators
| Recent close | $126.58 |
| 30d moving avg. | $123.95 |
| Annualized volatility | 16.9% |
| Relative strength (RSI) | 49 |
| Short interest (ETF) | 20.7% |
| Short interest (underlying) | 4.8% |
Distributions
Assets Under Management (mns)
Money Flows (mns)
Short Interest (as % of shares outstanding)
Long Money Flows (mns)
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Comparable ETFs Based on Overlap
| Ticker | Fund Name | Overlap vs. IBB |
Expenses vs. IBB |
ALTAR Score™ vs. IBB |
|---|---|---|---|---|
| IBBQ | Invesco Nasdaq Biotechnology ETF | 78.1% | -26 bp | 0.0% |
| BBH | VanEck Biotech ETF | 60.3% | -10 bp | +4.6% |
| FBT | First Trust NYSE Arca Biotechnology Index Fund | 47.0% | +11 bp | +4.0% |
| XBI | SPDR S&P BIOTECH ETF | 45.9% | -10 bp | -4.1% |
| BBP | Virtus LifeSci Biotech Products ETF | 35.1% | +34 bp | -4.3% |
| PBE | Invesco Biotechnology & Genome ETF | 31.5% | +13 bp | +1.6% |
| BMED | Future Health ETF | 31.5% | +40 bp | -0.1% |
| MNTL | Tema Neuroscience and Mental Health ETF | 31.3% | +30 bp | -1.6% |
| HELX | Franklin Genomic Advancements ETF | 30.2% | +5 bp | -0.9% |
| FTXH | First Trust Nasdaq Pharmaceuticals ETF | 29.9% | +15 bp | +10.3% |
Risk and Returns: IBB vs. Comps (1 YR)
Notes: Top 10 overlapping ETFs. Funds with insufficient history not shown. Some funds may overlap. Hover over data point for ticker symbol.
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Results & Estimates
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | ||
|---|---|---|---|---|---|---|---|---|
| Sales per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Earnings per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Dividends per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Book value per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- |
Return on Equity
Net Margins
EPS Revision Activity (6 mo. ago = 100%)
Compound Annual Growth Rates
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Valuation Metrics
| Fwd Est | 2024 | 2025 | 2026 | |
| Price-to-sales | --x | --x | --x | --x |
| Price-to-earnings | --x | --x | --x | --x |
| Price-to-cash flow | --x | --x | --x | --x |
| Price-to-growth | --x | --x | --x | --x |
| Price-to-book value | --x | --x | --x | --x |
| Yield | --% | --% | --x | --% |
Based on closing prices from 4/30/2025
Peer Group Comparison Sample data. Subscribe for access.
Price-to-Earnings
Price-to-Sales
Price-to-Book Value
Price-to-Cash Flow
Price-to-Growth
Dividend Yield
Historical Valuation Trends Sample data. Subscribe for access.
SHOWING:
Price-to-Earnings
Price-to-Earnings
IBB
Notes: Based on adjusted historical results for current fund constituents. May differ from results achieved by past fund constituents. Max P/E of 100x.
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ETF Research Center Rating
AVOID
Not worthwhile for most investors. A rating of AVOID is assigned to ETFs with ALTAR Scores in the lowest quintile (the bottom 20%) of their category. Often, funds in this category consist of stocks with little if any history or expectation of profitability, and as a result our fundamentally-driven analysis may be less relevant.
ALTAR Score™
IBB
0.7%
Cat. Avg
6.5%
ALTAR Score™ Calculation
Category Overview
There are 953 funds in the US Equity category, with an average ALTAR Score™
of 6.5% and a standard deviation of
2.7%. IBB's ALTAR Score™ is approximately
2.2 standard deviations
below
the category average. This places IBB in the 1st percentile among funds in the category.
Sell Side Consensus Rating
Sell-side recommendations on the ETF's individual constituents
IBBSELL
U/W
HOLD
O/W
BUY
Expense Analysis
| Peer Group | Passive US Equity ETFs |
| # of ETFs | 192 |
| Avg. Expense Ratio | 31.0 bp |
| Std. Deviation | 25.7 bp |
| IBB (45 bp) Percentile rank | 71 |
Peer Group Expense Ratio Distribution
Total Cost of Ownership (TCO) Comparison
| Expense (bp) (A) |
Avg. Bid/Ask (bp) (B) |
TCO (bp) (A)+(B) |
|
|---|---|---|---|
| IBB | 45.0 | 1.4 | 46.4 |
| Peer Avg. | 27.8 | 6.5 | 34.2 |
For a detailed cost analysis of this and any other ETF use the TCO Comparison Tool .