PBE
Invesco Biotechnology & Genome ETF
The Invesco Dynamic Biotechnology & Genome Portfolio ETF tracks a tiered equal-weighted index of companies principally engaged in biotechnology and genetic engineering.
US
EQUITY
Rules-Based
MANAGEMENT STYLE
230.6 M
ASSETS UNDER MGMT
58 bp
EXPENSES
Fund Basics
| Fund sponsor | Invesco |
| Category | US |
| Asset class | Equity |
| Website | link... |
| Inception date | Jun 23, 2005 |
| Assets (mns) | $231 |
| Expense ratio | 58 bp |
| Currency | USD |
Sector Breakdown
Fund Structure
| Regulation | Open-Ended Fund |
| Distributions | Quarterly |
| Taxation | 1099 |
| Stock selection | Multi-Factor |
| Weighting | Tiered |
| Holdings Transparency | Full |
| Derivatives-based | No |
| Options available | Yes |
| Currency hedged | No |
| Fund of funds | No |
Top 10 Holdings
Complete list +
| BIOGEN IDEC INC | 5.5 % |
| VERTEX PHARMACEUTICALS INC | 4.9 % |
| ILLUMINA INC | 4.8 % |
| INCYTE CORP | 4.8 % |
| AMGEN INC | 4.8 % |
| REGENERON PHARMACEUTICALS | 4.8 % |
| ROYALTY PHARMA PLC CLASS A | 4.7 % |
| GILEAD SCIENCES INC | 4.6 % |
| IONIS PHARMACEUTICALS, INC. | 4.2 % |
| UNITED THERAPEUTICS CORP | 3.7 % |
Constituent Breakdown
| Number of holdings | 28 |
| Herfindahl-Hirschman Index | 362 |
| Wgt avg mkt cap (mns) | $28,393 |
| Large cap (>$10bn) | 50.6% |
| Mid cap ($2-10bn) | 30.0% |
| Small cap (<$2bn) | 14.2% |
| Developed mkts. | 93.1% |
| Emerging mkts. | 0.0% |
Country Exposure
 |
UNITED STATES | 93.8 % |
Historical Performance
Standardized Performance (as of 09/30/2025)
| YTD | 1 YR | 2 YR | 3 YR | 5 YR | 10 YR | 20 YR | Incep. | |
|---|---|---|---|---|---|---|---|---|
| Price Returns | 5.0% | 0.1% | 10.7% | 5.8% | 4.3% | 4.3% | 7.4% | 8.0% |
| Dividend Yield | 0.3% | 0.3% | 0.2% | 0.1% | 0.1% | 0.2% | 0.2% | 0.2% |
| Total Returns | 5.4% | 0.4% | 10.9% | 6.0% | 4.4% | 4.6% | 7.6% | 8.2% | Ann. Volatility | 23.2% | 22.4% | 21.2% | 20.9% | 23.9% | 26.1% | 25.6% | 25.5% |
Market Correlations
| versus... | Beta | R-squared |
| S&P 500 | 0.99 | 63% |
| MSCI EAFE | 0.71 | 41% |
| MSCI Emg Mkts | 0.45 | 18% |
Liquidity Measures
| Avg. volume (000) | 4 |
| ADV traded (mns) | $0 |
| Turnover | 0.1% |
| Avg. Bid/Ask (% of price) | 0.20% |
Technical Indicators
| Recent close | $73.36 |
| 30d moving avg. | $70.60 |
| Annualized volatility | 16.7% |
| Relative strength (RSI) | 59 |
| Short interest | 0.0% |
Distributions
Assets Under Management (mns)
Money Flows (mns)
Short Interest (as % of shares outstanding)
Long Money Flows (mns)
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Comparable ETFs Based on Overlap
| Ticker | Fund Name | Overlap vs. |
Expenses vs. |
ALTAR Score™ vs. |
|---|---|---|---|---|
| FBT | First Trust NYSE Arca Biotechnology Index Fund | 48.1% | -2 bp | +2.0% |
| BBH | VanEck Biotech ETF | 37.3% | -23 bp | +5.4% |
| IBBQ | Invesco Nasdaq Biotechnology ETF | 34.8% | -39 bp | +0.2% |
| IBB | iShares Biotechnology ETF | 34.1% | -13 bp | -0.2% |
| FTXH | First Trust Nasdaq Pharmaceuticals ETF | 32.7% | +2 bp | +9.0% |
| BBP | Virtus LifeSci Biotech Products ETF | 31.8% | +21 bp | -1.7% |
| XBI | SPDR S&P BIOTECH ETF | 30.7% | -23 bp | -2.4% |
| FXH | First Trust Health Care AlphaDEX Fund | 22.1% | +4 bp | +8.2% |
| PJP | Invesco Pharmaceuticals ETF | 21.1% | -1 bp | +8.4% |
| HELX | Franklin Genomic Advancements ETF | 19.3% | -8 bp | -0.3% |
Risk and Returns: PBE vs. Comps (1 YR)
Notes: Top 10 overlapping ETFs. Funds with insufficient history not shown. Some funds may overlap. Hover over data point for ticker symbol.
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Results & Estimates
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | ||
|---|---|---|---|---|---|---|---|---|
| Sales per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Earnings per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Dividends per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- | |
| Book value per share | -- | -- | -- | -- | -- | -- | -- | |
| change (%) | -- | -- | -- | -- | -- | -- | -- |
Return on Equity
Net Margins
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Valuation Metrics
| Fwd Est | 2024 | 2025 | 2026 | |
| Price-to-sales | --x | --x | --x | --x |
| Price-to-earnings | --x | --x | --x | --x |
| Price-to-cash flow | --x | --x | --x | --x |
| Price-to-growth | --x | --x | --x | --x |
| Price-to-book value | --x | --x | --x | --x |
| Yield | --% | --% | --x | --% |
Based on closing prices from 10/22/2025
Peer Group Comparison Sample data. Subscribe for access.
Price-to-Earnings
Price-to-Sales
Price-to-Book Value
Price-to-Cash Flow
Price-to-Growth
Dividend Yield
Historical Valuation Trends Sample data. Subscribe for access.
SHOWING:
Price-to-Earnings
Price-to-Earnings
Notes: Based on adjusted historical results for current fund constituents. May differ from results achieved by past fund constituents. Max P/E of 100x.
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ETF Research Center Rating
AVOID
Not worthwhile for most investors. A rating of AVOID is assigned to ETFs with ALTAR Scores in the lowest quintile (the bottom 20%) of their category. Often, funds in this category consist of stocks with little if any history or expectation of profitability, and as a result our fundamentally-driven analysis may be less relevant.
ALTAR Score™
PBE
1.7%
Cat. Avg
5.6%
ALTAR Score™ Calculation
Category Overview
There are 995 funds in the US Equity category, with an average ALTAR Score™
of 5.6% and a standard deviation of
2.3%. PBE's ALTAR Score™ is approximately
1.7 standard deviations
below
the category average. This places PBE in the 5th percentile among funds in the category.
Sell Side Consensus Rating
Sell-side recommendations on the ETF's individual constituents
PBESELL
U/W
HOLD
O/W
BUY
Expense Analysis
| Peer Group | Rules-Based US Equity ETFs |
| # of ETFs | 627 |
| Avg. Expense Ratio | 46.1 bp |
| Std. Deviation | 32.8 bp |
| PBE (58 bp) Percentile rank | 64 |
Peer Group Expense Ratio Distribution
Total Cost of Ownership (TCO) Comparison
| Expense (bp) (A) |
Avg. Bid/Ask (bp) (B) |
TCO (bp) (A)+(B) |
|
|---|---|---|---|
| PBE | 58.0 | 19.8 | 77.8 |
| Peer Avg. | 46.1 | 15.6 | 61.7 |
For a detailed cost analysis of this and any other ETF use the TCO Comparison Tool .