SBIO
ALPS Medical Breakthroughs ETF
ALPS Medical Breakthroughs ETF is an exchange-traded fund incorporated in the USA. The ETF seeks investment results that correspond generally to the performance of its underlying index, the Poliwogg Medical Breakthroughs Index (ticker symbol: PMBI).
US
EQUITY
Rules-Based
MANAGEMENT STYLE
$ 206.8 M
ASSETS UNDER MGMT
50 bp
EXPENSES
Fund Basics
| Inception date | Dec 30, 2014 |
| Regulation | Open-Ended Fund |
| Fund Website | link... |
| Distributions | Annually |
| Currency | USD |
| Holdings Transparency | Full |
| Derivatives-based | No |
| Options available | Yes |
| Currency hedged | No |
| Fund of funds | No |
Top 10 Holdings
Complete list +
| CRINETICS PHARMACEUTICALS INC | 4.6 % |
| APOGEE THERAPEUTICS, INC. | 4.4 % |
| XENON PHARMACEUTICALS, INC. | 3.5 % |
| CG ONCOLOGY, INC. | 3.3 % |
| DIANTHUS THERAPEUTICS INC | 3.0 % |
| ORUKA THERAPEUTICS INC | 2.9 % |
| TRAVERE THERAPEUTICS, INC. | 2.8 % |
| DEFINIUM THERAPEUTICS INC | 2.5 % |
| VERADERMICS INC | 2.4 % |
| ACADIA PHARMACEUTICALS INC | 2.3 % |
Constituent Breakdown
| Number of holdings | 87 |
| Herfindahl-Hirschman Index | 185 |
| Wgt avg mkt cap (mns) | $2,653 |
| Large cap (>$10bn) | 56.8% |
| Mid cap ($2-10bn) | 27.0% |
| Small cap (<$2bn) | 0.0% |
| Developed mkts. | 86.8% |
| Emerging mkts. | 1.3% |
Sector Breakdown
Country Exposure
 |
UNITED STATES | 83.2 % |
 |
CHINA | 1.3 % |
 |
BELGIUM | 1.0 % |
 |
BRITAIN | 0.9 % |
 |
GERMANY | 0.7 % |
 |
SINGAPORE | 0.6 % |
Historical Performance
Standardized Performance (as of 06/30/2026)
| YTD | 1 YR | 2 YR | 3 YR | 5 YR | 10 YR | 20 YR | Incep. | |
|---|---|---|---|---|---|---|---|---|
| Price Returns | 26.2% | 115.0% | 38.7% | 27.0% | 5.7% | 11.1% | -- | 8.7% |
| Dividend Yield | 0.0% | 0.0% | 0.0% | 0.1% | 0.1% | 0.5% | -- | 0.5% |
| Total Returns | 26.2% | 115.0% | 38.7% | 27.1% | 5.8% | 11.6% | -- | 9.1% | Ann. Volatility | 34.2% | 30.6% | 32.1% | 30.9% | 34.0% | 33.2% | -- | 34.1% |
Market Correlations
| versus... | Beta | R-squared |
| S&P 500 | 1.11 | 20% |
| MSCI EAFE | 0.94 | 23% |
| MSCI Emg Mkts | 0.50 | 14% |
Liquidity Measures
| Avg. volume (000) | 56 |
| ADV traded (mns) | $4 |
| Turnover | 1.8% |
| Avg. Bid/Ask (% of price) | 0.38% |
Technical Indicators
| 30d moving avg. (EMA) | $61.57 |
| Relative strength (RSI) | 61 |
| MACD/Signal | 2.59/2.99 |
| Bollinger Bands (Upper/Lower) | $70.62/$57.16 |
| Short interest (% of AUM) | 1.3% |
Distributions
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Comparable ETFs Based on Overlap
| Ticker | Fund Name | Overlap vs. SBIO |
Expenses vs. SBIO |
ALTAR Score™ vs. SBIO |
|---|---|---|---|---|
| BBC | Virtus LifeSci Biotech Clinical Trials ETF | 29.7% | +29 bp | 0.0% |
| XBI | State Street SPDR S&P Biotech ETF | 26.1% | -15 bp | -0.2% |
| XPH | State Street SPDR S&P Pharmaceuticals ETF | 19.6% | -15 bp | -0.8% |
| IBRN | iShares Neuroscience and Healthcare ETF | 16.6% | -3 bp | 0.0% |
| BBP | Virtus LifeSci Biotech Products ETF | 15.5% | +29 bp | -3.6% |
| CANC | Tema Oncology ETF | 14.8% | +25 bp | -1.9% |
| PTH | Invesco Dorsey Wright Healthcare Momentum ETF | 12.5% | +10 bp | -1.2% |
| LFSC | F/m Emerald Life Sciences Innovation ETF | 11.9% | +29 bp | 0.0% |
Risk and Returns: SBIO vs. Comps (1 YR)
Notes: Top 10 overlapping ETFs. Funds with insufficient history not shown. Some funds may overlap. Hover over data point for ticker symbol.
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Results & Estimates (USD)
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | 2027 | ||
|---|---|---|---|---|---|---|---|---|---|
| Sales per share | -- | -- | -- | -- | -- | -- | -- | ||
| change (%) | -- | -- | -- | -- | -- | -- | -- | ||
| Earnings per share | -- | -- | -- | -- | -- | -- | -- | ||
| change (%) | -- | -- | -- | -- | -- | -- | -- | ||
| Dividends per share | -- | -- | -- | -- | -- | -- | -- | ||
| change (%) | -- | -- | -- | -- | -- | -- | -- | ||
| Book value per share | -- | -- | -- | -- | -- | -- | -- | ||
| change (%) | -- | -- | -- | -- | -- | -- | -- |
Return on Equity
Net Margins
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Valuation Metrics
| Fwd Est | 2025 | 2026 | 2027 | |
| Price-to-sales | --x | --x | --x | --x |
| Price-to-earnings | --x | --x | --x | --x |
| Price-to-cash flow | --x | --x | --x | --x |
| Price-to-growth | --x | --x | --x | --x |
| Price-to-book value | --x | --x | --x | --x |
| Yield | --% | --% | --x | --% |
Based on closing prices from 7/20/2026
Peer Group Comparison
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Historical Valuation Trends Sample data. Subscribe for access.
Notes: Based on adjusted historical results for current fund constituents. May differ from results achieved by past fund constituents. Max P/E of 100x.
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ETF Research Center Rating
0.0%
ALTAR SCORE™
PERCENTILE
AVOID
ETFRC RATING
There are 1,401 funds in the US Equity category with an average
ALTAR Score™ of 5.4% and a standard deviation
of 2.1%. SBIO's ALTAR Score™ is approximately 0.0 standard
deviations above the category average. This places SBIO in the percentile
among funds in the category.
Sell-Side Consensus
$69.68
PRICE TARGET
+6.9%
UPSIDE